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MHC class I molecule
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MHC class I molecule A molecule encoded to genes of the MHC which participates in antigen presentation to cytotoxic T (CD8+) cells.
RELATED TERMS--------------------------------------
Genes
Basic, functional units of heredity, each occupying a specific place on a chromosome.
Antigen
A substance which, when present in animal tissue, stimulates the production of antibodies
Cytotoxic
Capable of killing cells.
SIMILAR TERMS--------------------------------------
MHC class II molecule
A molecule encoded by genes of the MHC which participates in antigen presentation to helper T (CD4+) cells.
MHC restriction
The ability of T lymphocytes to respond only when they 'see' the appropriate antigen in association with "self" MHC class I or class II proteins on the antigen presenting cells.
PREVIOUS AND NEXT TERMS--------------------------------------
Macrophage
A large phagocytic cell of the mononuclear series found within tissues. Properties include phagocytosis, and antigen presentation to T cells.
Macrophage-activating factor (MAF)
Actually several lymphokines, including interferon, released by activated T cells, which together induce activation of macrophages, making them more efficient in phagocytosis and cytotoxicity.
Major histocompatibility complex (MHC)
A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigens which lead to rapid graft rejection between members of a single species which differ at these loci. Several classes of protein such as MHC class I and II proteins are encoded in this region. These in humans, are known as 'Human leukocyte antigens' (HLA).
Mast cell
Tissue located cell probably derived from basophils. Possesses receptor for Fc of IgE. Participates in 'Immediate hypersensitivity' reactions.
Memory
In the immune system, memory denotes an active state of immunity to a specific antigen, such that a second encounter with that antigen leads to a larger and more rapid response.
MHC class I molecule
MHC class II molecule
A molecule encoded by genes of the MHC which participates in antigen presentation to helper T (CD4+) cells.
MHC restriction
The ability of T lymphocytes to respond only when they 'see' the appropriate antigen in association with "self" MHC class I or class II proteins on the antigen presenting cells.
Migration inhibition factor (MIF)
A lymphokine that inhibits the motility of macrophages in culture.
Minor histocompatibility antigens
These antigens, encoded outside the MHC, are numerous, but do not generate rapid graft rejection or primary responses of T cells in vitro. They do not serve as restricting elements in cell interactions.
Mitogen
A substance that stimulates the proliferation of many different clones of lymphocytes.
RELATED TERMS--------------------------------------
Genes
Basic, functional units of heredity, each occupying a specific place on a chromosome.
Antigen
A substance which, when present in animal tissue, stimulates the production of antibodies
Cytotoxic
Capable of killing cells.
SIMILAR TERMS--------------------------------------
MHC class II molecule
A molecule encoded by genes of the MHC which participates in antigen presentation to helper T (CD4+) cells.
MHC restriction
The ability of T lymphocytes to respond only when they 'see' the appropriate antigen in association with "self" MHC class I or class II proteins on the antigen presenting cells.
PREVIOUS AND NEXT TERMS--------------------------------------
Macrophage
A large phagocytic cell of the mononuclear series found within tissues. Properties include phagocytosis, and antigen presentation to T cells.
Macrophage-activating factor (MAF)
Actually several lymphokines, including interferon, released by activated T cells, which together induce activation of macrophages, making them more efficient in phagocytosis and cytotoxicity.
Major histocompatibility complex (MHC)
A cluster of genes on chromosome 6 in humans, encoding cell surface molecules that are polymorphic and that code for antigens which lead to rapid graft rejection between members of a single species which differ at these loci. Several classes of protein such as MHC class I and II proteins are encoded in this region. These in humans, are known as 'Human leukocyte antigens' (HLA).
Mast cell
Tissue located cell probably derived from basophils. Possesses receptor for Fc of IgE. Participates in 'Immediate hypersensitivity' reactions.
Memory
In the immune system, memory denotes an active state of immunity to a specific antigen, such that a second encounter with that antigen leads to a larger and more rapid response.
MHC class I molecule
MHC class II molecule
A molecule encoded by genes of the MHC which participates in antigen presentation to helper T (CD4+) cells.
MHC restriction
The ability of T lymphocytes to respond only when they 'see' the appropriate antigen in association with "self" MHC class I or class II proteins on the antigen presenting cells.
Migration inhibition factor (MIF)
A lymphokine that inhibits the motility of macrophages in culture.
Minor histocompatibility antigens
These antigens, encoded outside the MHC, are numerous, but do not generate rapid graft rejection or primary responses of T cells in vitro. They do not serve as restricting elements in cell interactions.
Mitogen
A substance that stimulates the proliferation of many different clones of lymphocytes.
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This dictionary contains 19186 terms.
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