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Fish-odor syndrome
Fish-odor syndromeAn inborn error of metabolism associated with an offensive body odor, the smell of rotting fish, due to the excessive excretion of trimethylaminuria (TMA) in urine, sweat, and breath. Persons with TMA may experience tachycardia (fast heart rate) and severe hypertension (high blood pressure) after eating cheese (which contains tyramine) and after using nasal sprays containing epinephrine. TMA is caused by a mutation (change) in the gene for an enzyme, flavin-containing monooxygenase-3 (FMO3) encoded by a gene on chromosome #1. The FMO3 enzyme metabolizes tyramine (which is in cheese). The syndrome is associated with various psychosocial reactions, including social isolation, clinical depression and attempted suicide. RELATED TERMS-------------------------------------- Metabolism The chemical activity that occurs in cells, releasing energy from nutrients, or using energy to create other substances, such as proteins. Fish Abbreviation for fluorescence in situ hybridization, a molecular technique used in chromosome studies. FISH employs fluorescent (fluorescein tags) that glow under ultraviolet light to detect the hybridization (the combination) of molecular probes with specific chromosomes and specific chromosome regions. In FISH, the process vividly paints chromosomes or portions of chromosomes with fluorescent molecules. Urine The waste fluid secreted by the kidneys, transported by the ureters, stored in the bladder, and voided through the urethra. Tachycardia Rapid heart beat. Heart The hollow, muscular organ responsible for pumping blood through the circulatory system. Hypertension Higher blood pressure than normal. Diastolic blood pressure from 90 to 99 mm HG is considered mild hypertension; 100–109, moderate hypertension; and 110 or greater, severe hypertension. Systolic blood pressure from 140 to 159 mm HG is considered mild hypertension; 160–179, moderate hypertension; and 180 or greater, severe hypertension. Blood The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues. Epinephrine One of two chemicals (the other is norepinephrine) released by the adrenal gland that increases the speed and force of heart beats. It dilates the airways to improve breathing and narrows blood vessels in the skin and intestine so that an increased flow of blood reaches the muscles and allows them to cope with the demands of exercise. Mutation A change in DNA that alters a gene and thus the gene's product, leading in some cases to deformity or disease. Mutations can occur spontaneously during cell division or can be triggered by environmental stresses, such as sunlight, radiation, and chemicals. Gene 1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism. Enzyme A cellular protein whose shape allows it to hold together several other molecules in close proximity to each other. In this way, enzymes are able to induce chemical reactions in other substances with little expenditure of energy and without being changed themselves. Basically, an enzyme acts as a catalyst. Chromosome A structural unit within a eukaryotic nucleus that carries genes. A chromosome consists of a long, continuous strand of DNA and associated proteins. FMO3 Abbreviation for the enzyme, flavin-containing monooxygenase-3. Syndrome A grouping of signs and symptoms, based on their frequent co-occurrence, that may suggest a common underlying pathogenesis, course, familial pattern, or treatment selection. Social worker An individual, usually with a university degree in social work, who provides counsel and aid to individuals with emotional and family problems. Isolation A defense mechanism operating unconsciously central to obsessive-compulsive phenomena in which the affect is detached from an idea and rendered unconscious, leaving the conscious idea colorless and emotionally neutral. Clinical That which can be observed in patients. Research that uses patients to test new treatments, as opposed to laboratory testing or research in animals. Depression A mental state of depressed mood characterized by feelings of sadness, despair and discouragement. Depression ranges from normal feelings of the blues through dysthymia to major depression. It in many ways resembles the grief and mourning that follow bereavement, there are often feelings of low self esteem, guilt and self reproach, withdrawal from interpersonal contact and physical symptoms such as eating and sleep disturbances. Suicide The act of killing oneself. SIMILAR TERMS-------------------------------------- FISH Abbreviation for fluorescence in situ hybridization, a molecular technique used in chromosome studies. FISH employs fluorescent (fluorescein tags) that glow under ultraviolet light to detect the hybridization (the combination) of molecular probes with specific chromosomes and specific chromosome regions. In FISH, the process vividly paints chromosomes or portions of chromosomes with fluorescent molecules. Fish bowl granuloma Localized nodular skin inflammation (small reddish raised areas of skin) caused by a bacterium called mycobacterium marinum. Fish bowl granuloma is typically acquired by occupational or recreational exposure to salt or fresh water, often resulting from minor trauma during caring for aquariums. The diagnosis is suggested by the history of exposure and confirmed by culturing tissue specimens which yield the microscopic organism, mycobacterium marinum. The infection can be treated with a variety of antibiotics, including doxycycline, minocycline, clarithromycin, rifampin, and trimethoprim-sulfamethoxazole. Also called "swimming pool granuloma." Fish oil, omega-3 A class of fatty acids found in fish oils, especially from salmon and other cold-water fish, that acts to lower the levels of cholesterol and LDL (low-density lipoproteins) in the blood. (LDL cholesterol is the "bad" cholesterol.) Omega-3 fish oil is therefore thought to be a neutraceutical, a food that provides health benefits. Eating fish has been reported to protect against late age-related macular degeneration, a common eye disease. The maximum benefit appears to be from eating fish once a week. Fisher-Titus Medical Center Fisher-Titus Medical Center is a hospital in Norwalk, Ohio (USA). PREVIOUS AND NEXT TERMS-------------------------------------- First degree burn A superficial burn with similar characteristics to a typical sun burn. The skin is red in color and sensation is intact. In fact, it is usually somewhat painful. First stage of labor The part of labor when the cervix dilates fully (to 10 centimeters). The first stage of labor is also called the stage of dilatation. FISH Abbreviation for fluorescence in situ hybridization, a molecular technique used in chromosome studies. FISH employs fluorescent (fluorescein tags) that glow under ultraviolet light to detect the hybridization (the combination) of molecular probes with specific chromosomes and specific chromosome regions. In FISH, the process vividly paints chromosomes or portions of chromosomes with fluorescent molecules. Fish bowl granuloma Localized nodular skin inflammation (small reddish raised areas of skin) caused by a bacterium called mycobacterium marinum. Fish bowl granuloma is typically acquired by occupational or recreational exposure to salt or fresh water, often resulting from minor trauma during caring for aquariums. The diagnosis is suggested by the history of exposure and confirmed by culturing tissue specimens which yield the microscopic organism, mycobacterium marinum. The infection can be treated with a variety of antibiotics, including doxycycline, minocycline, clarithromycin, rifampin, and trimethoprim-sulfamethoxazole. Also called "swimming pool granuloma." Fish oil, omega-3 A class of fatty acids found in fish oils, especially from salmon and other cold-water fish, that acts to lower the levels of cholesterol and LDL (low-density lipoproteins) in the blood. (LDL cholesterol is the "bad" cholesterol.) Omega-3 fish oil is therefore thought to be a neutraceutical, a food that provides health benefits. Eating fish has been reported to protect against late age-related macular degeneration, a common eye disease. The maximum benefit appears to be from eating fish once a week. Fish-odor syndrome Fissure, palpebral The opening for the eye between the eyelids. Fistula, anal An opening in the skin near the anus that leads into a blind pouch or may connect through a tunnel with the rectal canal. Five-day fever Also called trench fever, this is a disease borne by body lice that was first recognized in the trenches of World War I, when it is estimated to have affected more than a million people in Russia and on the fronts in Europe. Trench fever was again a major problem in the military in World War II and is seen endemically in Mexico, Africa, E. Europe, and elsewhere. The cause of trench fever is Bartonella quintana (also called Rochalimaea quintana), an unusual rickettsial organism that multiplies in the gut of the body louse. Transmission of the rickettsia to people can occur by rubbing infected louse feces into abraded (scuffed) skin or into the conjunctivae (whites of the eyes). The disease is classically a 5-day fever. The onset of symptoms is sudden with high fever, severe headache, back pain and leg pain and a fleeting rash. Recovery takes a month or more. Relapses are common. Five-lipoxygenase activating protein A gene that helps make a leukotriene, a signal that activates the white blood cells involved in inflammation. FLAP stands for 5-lipoxygenase-activating protein. FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene discovered to be a major risk factor for the common form of heart attack and the second major genetic factor identified in the common form of stroke. Fixation, external A procedure that stabilizes and joins the ends of fractured (broken) bones by a splint or cast. External fixation is as opposed to internal fixation in which the ends of the fractured bone are joined by mechanical devices such as metal plates, pins, rods, wires or screws. We thank you for using the Medical Glossary to search for Fish-odor syndrome. If you have a better definition for Fish-odor syndrome than the one presented here, please let us know by making use of the suggest a term option. This definition of Fish-odor syndrome may be disputed by other professionals. Our attempt is to provide easy definitions on Fish-odor syndrome and any other medical topic for the public at large.
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