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Cryoglobulin
Cryoglobulin"An abnormal blood protein that has the unusual properties of precipitating from the blood serum when it is chilled (hence the ""cryo-"") and redissolving when it is rewarmed. Cryoglobulins are gamma globulins with a molecular weight of approximately 200,000. " RELATED TERMS-------------------------------------- Abnormal Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer). Blood The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues. Protein Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others. Serum The fluid portion of the blood. It is essentially similar in composition to plasma but lacks fibrinogen and other substances that are used in the coagulation (blood clotting) process. Molecular Refers to the basic building blocks of the genetic material, such as DNA, genes and the other chemicals involved with the functioning of genes. SIMILAR TERMS-------------------------------------- Cryo-electron microscopy An electron microscopic technique that involves freezing the biological sample in order to view the sample with the least possible distortion and the fewest possible artifacts. Abbreviated as cryo-EM. Cryo-EM Cryo-electron microscopy. Cryocardioplegia Paralysis of the heart by cold (hypothermia). Cryoglobuliaemia Phenomenon of precipitation of immunoglobulins in serum on exposure to cold. Associated with vasculitis and Raynaud's phenomenon. Cryoglobulinemia The presence in blood of abnormal proteins called cryoglobulins that, by definition, have the unusual properties of precipitating from the blood serum when it is chilled and redissolving upon rewarming. (Cryoglobulins are gamma globulins with a molecular weight of approximately 200,000.) Cryophobia An abnormal and persistent fear of cold, including cold weather and cold objects. Sufferers from cryophobia experience anxiety even though they realize their fear is irrational. To avoid cold, they may live in a warm climate, dress more warmly than necessary, stay indoors on cold days, and avoid cold foods and ice cubes. Cryopreservation To preserve by freezing. Bone marrow harvested for an autologous BMT, for example, is cryopreserved. Cryoprobe A surgical probe, a long slender pointed surgical instrument, used to apply extreme cold to tissues. Cryoprostatectomy Freezing of the prostate through the use of liquid nitrogen probes guided by transrectal ultrasound of the prostate. Cryoprotectant A chemical component of a freezing solution used in cryopreservation (the process of cooling and storing cells, tissues, or organs at very low temperatures to maintain viability). The purpose of the cryoprotectant is to help protect what is being frozen from freeze damage. Cryostat A chamber that can maintain very low temperatures. Medical laboratories use a cryostat to preserve frozen tissue samples while a microtome, an extremely sharp cutting instrument mounted inside cryostats, slices the tissue into pieces thin enough to be observed under a microscope. The sliced piece must be so thin as to look nearly transparent. A pathologist, a laboratory doctor trained to identify evidence of disease in microscopic structures, then examines the slice to confirm or rule out the presence of a disease, such as cancer. Use of frozen tissue samples enables physicians to examine tissue and diagnose its condition more quickly than if the tissue had been preserved without freezing. Cryosurgery The use of extreme cold (usually liquid nitrogen) to destroy unwanted tissue (warts or cataracts or skin cancers). Cryothalamotomy A surgical procedure in which a supercooled probe is inserted into a part of the brain called the thalamus in order to stop tremors. Cryotherapy Technique using liquid nitrogen, for example, to freeze warts and precancerous lesions. PREVIOUS AND NEXT TERMS-------------------------------------- Crutch A wooden or metal vertical prop that helps support a disabled person while he or she is walking. Crutches extend from the walking surface to either the armpit or the arm. Cry for help An expression of suicidal intent in the hope of receiving help and being rescued. A cry for help may take many different forms such as a telephone call, a message left on an answering phone, a note left in a conspicuous place, or an e-mail message. It may also be a symbolic gesture such as a superficial cut on the wrist. Cryo-electron microscopy An electron microscopic technique that involves freezing the biological sample in order to view the sample with the least possible distortion and the fewest possible artifacts. Abbreviated as cryo-EM. Cryo-EM Cryo-electron microscopy. Cryocardioplegia Paralysis of the heart by cold (hypothermia). Cryoglobulin Cryoglobulinemia The presence in blood of abnormal proteins called cryoglobulins that, by definition, have the unusual properties of precipitating from the blood serum when it is chilled and redissolving upon rewarming. (Cryoglobulins are gamma globulins with a molecular weight of approximately 200,000.) Cryophobia An abnormal and persistent fear of cold, including cold weather and cold objects. Sufferers from cryophobia experience anxiety even though they realize their fear is irrational. To avoid cold, they may live in a warm climate, dress more warmly than necessary, stay indoors on cold days, and avoid cold foods and ice cubes. Cryoprobe A surgical probe, a long slender pointed surgical instrument, used to apply extreme cold to tissues. Cryoprotectant A chemical component of a freezing solution used in cryopreservation (the process of cooling and storing cells, tissues, or organs at very low temperatures to maintain viability). The purpose of the cryoprotectant is to help protect what is being frozen from freeze damage. Cryostat A chamber that can maintain very low temperatures. Medical laboratories use a cryostat to preserve frozen tissue samples while a microtome, an extremely sharp cutting instrument mounted inside cryostats, slices the tissue into pieces thin enough to be observed under a microscope. The sliced piece must be so thin as to look nearly transparent. A pathologist, a laboratory doctor trained to identify evidence of disease in microscopic structures, then examines the slice to confirm or rule out the presence of a disease, such as cancer. Use of frozen tissue samples enables physicians to examine tissue and diagnose its condition more quickly than if the tissue had been preserved without freezing. We thank you for using the Medical Glossary to search for Cryoglobulin. If you have a better definition for Cryoglobulin than the one presented here, please let us know by making use of the suggest a term option. This definition of Cryoglobulin may be disputed by other professionals. Our attempt is to provide easy definitions on Cryoglobulin and any other medical topic for the public at large.
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