Medical Glossary

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Chondroitin sulfate




Chondroitin sulfate

A glycosaminoglycan (formerly called a mucopolysaccharide) found in cartilage, bone, blood vessels and connective tissues. There are two forms: chondroitin sulfate A and chondroitin sulfate C. One or both types accumulate abnormally in several of the mucopolysaccharidosis disorders. Chondroitin sulfate B is now called dermatan sulfate.

RELATED TERMS
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Cartilage
A firm, flexible connective tissue. In vertebrates, the cartilage forms the skeleton in the early stages of development, after which it is largely replaced by bone. Some cartilage remains at the joints to give flexibility and support.

Bone
Bone refers either to a hardened connective tissue or to one of the individual structures, or organs, into which it is formed, found in many animals. Bones support body structures, protect internal organs, and (in conjunction with muscles) facilitate movement; are also involved with cell formation, calcium metabolism, and mineral storage. The bones of an animal are, collectively, known as the skeleton.

Blood
The life-maintaining fluid which is made up of plasma, red blood cells (erythrocytes), white blood cells (leukocytes), and platelets; blood circulates through the body's heart, arteries, veins, and capillaries; it carries away waste matter and carbon dioxide, and brings nourishment, electrolytes, hormones, vitamins, antibodies, heat, and oxygen to the tissues.



SIMILAR TERMS
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Chondritis
Inflammation of the cartilage.

Chondrocalcinosis
Calcification of articular cartilage. May be associated with attacks of joint inflammation that may mimic gout ('Pseudogout').

Chondrodysplasia
Congenital condition in which there is a mutation of a collagen-associated gene.

Chondromalacia
Softening of cartilage.

Chondromalacia patellae
A condition in which knee pain results from wear of the cartilage at the back of the kneecap (patella).

Chondroplasia
The formation of cartilage by specialized cells called chondrocytes.

Chondrosarcoma
A malignant tumor that forms in cartilage cells (chondroplasts) and that produces cartilage matrix. Chondrosarcoma can be primary or secondary. Primary chondrosarcoma forms in bone and is found in children. Secondary chondrosarcoma arises from preexisting benign defects of cartilage (such as an osteochondroma or enchondroma), usually after age 40. Treatment is mainly by surgery.



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Cholera genome
The genome of the bacterium called Vibrio cholerae that causes cholera. This genome contains over 4 million bases in its DNA including the sequences for nearly 4,000 genes.

Cholestasis with peripheral pulmonary stenosis
Also known as arteriohepatic dysplasia or Alagille syndrome, this ia a genetic disorder characterized by yellowing of the skin (jaundice) in the newborn period, liver disease with cholestasis, peripheral pulmonic stenosis and unusual face. Children with Alagille syndrome usually present with jaundice (yellowing of the skin and whites of the eyes) in the newborn period. Cholestasis (stagnant flow of bile from the liver) then develops with puritis (itching), stools without the usual yellowing brown color, and enlargement of the liver and spleen. Peripheral pulmonic stenosis is a form of congenital heart disease (CHD). Other types of CHD also occur. The face has deep- set eyes, broad forehead, long nose with flat tip, prominence of the chin, and low-set or malformed ears. The outlook (prognosis) depends upon the degree of severity of the CHD and the liver disease (it can cause liver failure). The condition is an autosomal dominant trait meaning that the gene for it is on a non-sex chromosome (an autosome) and a single edition of the Alagille gene is sufficient to produce the disease. The gene has been discovered on chromosome 20 in band 20p12

Cholesterol ester transfer protein
A protein that helps regulate the size of cholesterol particles and influence the process of atherogenesis (the formation of plaques in arteries). Abbreviated CETP. The CETP gene is in chromosome band 16q21. A number of mutations are known in the CETP gene. Some result in CEPT deficiency, increased levels of HDL ("good") cholesterol and unusually large cholesterol particles. CETP deficiency appears to be a good mutation which is antiatherogenic and may confer unusual longevity to the person. Also called cholesteryl ester transfer protein.

Cholesterol guidelines
The guidelines on cholesterol for adults.

Cholestin
One of the three major preparations of red yeast rice, a tradition Chinese medicine now used to lower cholesterol. Cholestin is also known as Hypocol.

Chondroitin sulfate

Chondroplasia
The formation of cartilage by specialized cells called chondrocytes.

Chondrosarcoma
A malignant tumor that forms in cartilage cells (chondroplasts) and that produces cartilage matrix. Chondrosarcoma can be primary or secondary. Primary chondrosarcoma forms in bone and is found in children. Secondary chondrosarcoma arises from preexisting benign defects of cartilage (such as an osteochondroma or enchondroma), usually after age 40. Treatment is mainly by surgery.

Chorda tympani
A branch of the facial nerve (the seventh cranial nerve) that serves the taste buds in the front of the tongue, runs through the middle ear, and carries taste messages to the brain.

Chordae tendineae
Thread-like bands of fibrous tissue which attach on one end to the edges of the tricuspid and mitral valves of the heart and on the other end to the papillary muscles, small muscles within the heart that serve to anchor the valves.

Chordoma
A form of bone cancer that usually starts in the lower spinal column.

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This dictionary contains 19186 terms.







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