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COX
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COX Prostaglandins can be of either COX-1 or COX-2 type. COX-2 are inflammatory and COX-1 are cytoprotective - e.g. to gastric mucosa.
RELATED TERMS--------------------------------------
Prostaglandins
Molecules produced by the breakdown of arachidonic acid (from cell membranes) by cyclo-oxygenase. Most are inflammatory but some suppress inflammation.
COX-1
Cyclooxygenase-1, a protein that acts as an enzyme to speed up the production of certain chemical messengers, called prostaglandins, within the stomach. The prostaglandins work within certain cells that are responsible for inflammation and other functions. For example, they promote the production of the natural mucus lining that protects the inner stomach. Cox-1 is normally present in a variety of areas of the body, including not only the stomach but any other site of inflammation.
COX-2
Cyclooxygenase-2, a protein acts as an enzyme and specifically catalyzes (speeds) the production of certain chemical messengers called prostaglandins. Some of these messengers are responsible for promoting inflammation. When Cox-2 activity is blocked, inflammation is reduced. Unlike cox-1, cox-2 is active only at the site of inflammation, not in the stomach.
Gastric
Related to the stomach.
Mucosa
The membrane covering canals and cavities that open on the outside of the body, such as the gastrointestinal tract and the respiratory tract. Also called mucous membrane.
SIMILAR TERMS--------------------------------------
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Collagen
At a microscopic level, this is the 'skeleton' of most tissues in the body.
Collagen disease
See 'Connective tissue disease'.
Colles fracture
Fracture of distal radius and ulna just proximal to the wrist.
Connective tissue disease
Connective tissue diseases are inflammatory multisystem diseases characterised by evidence of autoimmunity (e.g. antibodies to cellular components) in which there are often prominent signs of involvement of the joints and other parts of the locomotor system. e.g. SLE.
Corticosteroids
Sometimes referred to just as 'steroids'. Hormones (which occur naturally) which have a variety of actions when given therapeutically. Usually administered for their anti-inflammatory effect. Their use is limited by unwanted side-effects which may sometimes be serious.
COX
Cranial arteritis
A vasculitic disorder which presents with head pain and scalp tenderness and a high ESR. Sudden loss of vision may occur due to retinal artery occlusion. Part of the polymyalgia rheumatica disease spectrum. Also known as giant cell or temporal arteritis.
C-reactive protein
A protein produced by the liver. An acute-phase reactant whose quantity serves as a guide to the presence and severity of inflammation.
Crepitus
Grating sensation or sound which may be appreciated on joint movement - signifies roughness of joint surfaces.
CREST Syndrome
Calcinosis, Raynaud's phenomenon, (O)Esophageal dysmotility, Sclerodactyly and Telangectasia. A variant of scleroderma - now usually referred to as Limited Cutaneous Scleroderma
RELATED TERMS--------------------------------------
Prostaglandins
Molecules produced by the breakdown of arachidonic acid (from cell membranes) by cyclo-oxygenase. Most are inflammatory but some suppress inflammation.
COX-1
Cyclooxygenase-1, a protein that acts as an enzyme to speed up the production of certain chemical messengers, called prostaglandins, within the stomach. The prostaglandins work within certain cells that are responsible for inflammation and other functions. For example, they promote the production of the natural mucus lining that protects the inner stomach. Cox-1 is normally present in a variety of areas of the body, including not only the stomach but any other site of inflammation.
COX-2
Cyclooxygenase-2, a protein acts as an enzyme and specifically catalyzes (speeds) the production of certain chemical messengers called prostaglandins. Some of these messengers are responsible for promoting inflammation. When Cox-2 activity is blocked, inflammation is reduced. Unlike cox-1, cox-2 is active only at the site of inflammation, not in the stomach.
Gastric
Related to the stomach.
Mucosa
The membrane covering canals and cavities that open on the outside of the body, such as the gastrointestinal tract and the respiratory tract. Also called mucous membrane.
SIMILAR TERMS--------------------------------------
PREVIOUS AND NEXT TERMS--------------------------------------
Collagen
At a microscopic level, this is the 'skeleton' of most tissues in the body.
Collagen disease
See 'Connective tissue disease'.
Colles fracture
Fracture of distal radius and ulna just proximal to the wrist.
Connective tissue disease
Connective tissue diseases are inflammatory multisystem diseases characterised by evidence of autoimmunity (e.g. antibodies to cellular components) in which there are often prominent signs of involvement of the joints and other parts of the locomotor system. e.g. SLE.
Corticosteroids
Sometimes referred to just as 'steroids'. Hormones (which occur naturally) which have a variety of actions when given therapeutically. Usually administered for their anti-inflammatory effect. Their use is limited by unwanted side-effects which may sometimes be serious.
COX
Cranial arteritis
A vasculitic disorder which presents with head pain and scalp tenderness and a high ESR. Sudden loss of vision may occur due to retinal artery occlusion. Part of the polymyalgia rheumatica disease spectrum. Also known as giant cell or temporal arteritis.
C-reactive protein
A protein produced by the liver. An acute-phase reactant whose quantity serves as a guide to the presence and severity of inflammation.
Crepitus
Grating sensation or sound which may be appreciated on joint movement - signifies roughness of joint surfaces.
CREST Syndrome
Calcinosis, Raynaud's phenomenon, (O)Esophageal dysmotility, Sclerodactyly and Telangectasia. A variant of scleroderma - now usually referred to as Limited Cutaneous Scleroderma
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This dictionary contains 19186 terms.
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