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Altretamine
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AltretamineBrand name: Hexalen. An oral drug used to treat ovarian cancer that has persisted or has recurred following treatment with other anti-cancer drugs. It was approved for this use by the FDA in 1990. Altretamine also has been used for treating lung cancer, although this is an off-label use.
RELATED TERMS--------------------------------------
Hexalen
Hexalen is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): altretamine.
Oral
Of or involving the mouth or mouth region or the surface on which the mouth is located.
Cancer
Any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream.
Altretamine
Brand name: Hexalen. An oral drug used to treat ovarian cancer that has persisted or has recurred following treatment with other anti-cancer drugs. It was approved for this use by the FDA in 1990. Altretamine also has been used for treating lung cancer, although this is an off-label use.
SIMILAR TERMS--------------------------------------
PREVIOUS AND NEXT TERMS--------------------------------------
Alternative splicing
A mechanism by which different forms of mature mRNAs (messengers RNAs) are generated from the same gene. Alternative splicing is a regulatory mechanism by which variations in the incorporation of the exons, or coding regions, into mRNA leads to the production of more than one related protein, or isoform.
Altitude illness
"Altitude illness (or altitude sickness) is a disorder caused by being at high altitude. It commonly occurs above 8,000 feet (2,440 meters). The cause of altitude illness is a matter of oxygen physiology. At sea level the concentration of oxygen is about 21% and the barometric pressure averages 760 mmHg. As altitude increases, the concentration remains the same but the number of oxygen molecules per breath is reduced. At 12,000 feet (3,658 meters) the barometric pressure is only 483 mmHg, so there are roughly 40% fewer oxygen molecules per breath. In order to oxygenate the body effectively, your breathing rate (even while at rest) has to increase. This extra ventilation increases the oxygen content in the blood, but not to sea level concentrations. Since the amount of oxygen required for activity is the same, the body must adjust to having less oxygen. In addition, high altitude and lower air pressure cause fluid to leak from the capillaries which can cause fluid build-up in both the lungs and the brain. Continuing to higher altitudes without proper acclimatization can lead to potentially serious, even life-threatening illnesses.
Altitude, acclimatization to
Adjustment to changes in altitude. The main cause of altitude sickness is going too high too fast. Given time, the body can adapt to the decrease in oxygen concentration at a specific altitude, process known as acclimatization.
Altitude, high
Altitude sickness occurs at high altitude.
Altretamine
Aluminum poisoning
See: Aluminum.
Aluminum toxicity
See: Aluminum.
Alveolar
"Pertaining to the alveoli, the tiny air sacs in the lungs. The exchange of oxygen and carbon dioxide takes place in the alveoli which look like cells in a honeycomb. The word comes from the Latin diminutive of ""alveus"" meaning a cavity or hollow = a little cavity or hollow."
Alveolar hydatid disease
"Abbreviated AHD. A parasitic disease caused by the larval stage of a microscopic tapeworm Echinococcus multilocularis. AHD is found worldwide, mostly in northern latitudes. in central Europe, Russia, China, Central Asia, Japan, and North America. In North America E. multilocularis is found primarily in the north central region from eastern Montana to central Ohio, as well as in Alaska and Canada. Human cases have been reported in Alaska, the province of Manitoba, and Minnesota. Prevalence among wild foxes and coyotes is high, and may reach over 50% in some areas; however, even in these areas, transmission to humans has been low. Wild foxes, coyotes, and cats get infected when they eat Echinococcus multilocularis larvae in infected rodents, field mice, or voles. Cats are less susceptible than dogs, but because they probably catch and eat rodents more often, may also become infected. Once the animal becomes infected, the tapeworm matures in its intestine, lays eggs, and the infected animal passes eggs in the stool. These tapeworm eggs, which are directly infectious to other animals, are too tiny to see, and will stick to anything with which they come in contact. Coyotes, foxes, dogs, and cats are not harmed by the tapeworm and do not have symptoms of AHD.
Alveolar proteinosis
See: Pulmonary alveolar proteinosis.
RELATED TERMS--------------------------------------
Hexalen
Hexalen is a prescription or over-the-counter drug which is (or once was) approved in the United States and possibly in other countries. Active ingredient(s): altretamine.
Oral
Of or involving the mouth or mouth region or the surface on which the mouth is located.
Cancer
Any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream.
Altretamine
Brand name: Hexalen. An oral drug used to treat ovarian cancer that has persisted or has recurred following treatment with other anti-cancer drugs. It was approved for this use by the FDA in 1990. Altretamine also has been used for treating lung cancer, although this is an off-label use.
SIMILAR TERMS--------------------------------------
PREVIOUS AND NEXT TERMS--------------------------------------
Alternative splicing
A mechanism by which different forms of mature mRNAs (messengers RNAs) are generated from the same gene. Alternative splicing is a regulatory mechanism by which variations in the incorporation of the exons, or coding regions, into mRNA leads to the production of more than one related protein, or isoform.
Altitude illness
"Altitude illness (or altitude sickness) is a disorder caused by being at high altitude. It commonly occurs above 8,000 feet (2,440 meters). The cause of altitude illness is a matter of oxygen physiology. At sea level the concentration of oxygen is about 21% and the barometric pressure averages 760 mmHg. As altitude increases, the concentration remains the same but the number of oxygen molecules per breath is reduced. At 12,000 feet (3,658 meters) the barometric pressure is only 483 mmHg, so there are roughly 40% fewer oxygen molecules per breath. In order to oxygenate the body effectively, your breathing rate (even while at rest) has to increase. This extra ventilation increases the oxygen content in the blood, but not to sea level concentrations. Since the amount of oxygen required for activity is the same, the body must adjust to having less oxygen. In addition, high altitude and lower air pressure cause fluid to leak from the capillaries which can cause fluid build-up in both the lungs and the brain. Continuing to higher altitudes without proper acclimatization can lead to potentially serious, even life-threatening illnesses.
Altitude, acclimatization to
Adjustment to changes in altitude. The main cause of altitude sickness is going too high too fast. Given time, the body can adapt to the decrease in oxygen concentration at a specific altitude, process known as acclimatization.
Altitude, high
Altitude sickness occurs at high altitude.
Altretamine
Aluminum poisoning
See: Aluminum.
Aluminum toxicity
See: Aluminum.
Alveolar
"Pertaining to the alveoli, the tiny air sacs in the lungs. The exchange of oxygen and carbon dioxide takes place in the alveoli which look like cells in a honeycomb. The word comes from the Latin diminutive of ""alveus"" meaning a cavity or hollow = a little cavity or hollow."
Alveolar hydatid disease
"Abbreviated AHD. A parasitic disease caused by the larval stage of a microscopic tapeworm Echinococcus multilocularis. AHD is found worldwide, mostly in northern latitudes. in central Europe, Russia, China, Central Asia, Japan, and North America. In North America E. multilocularis is found primarily in the north central region from eastern Montana to central Ohio, as well as in Alaska and Canada. Human cases have been reported in Alaska, the province of Manitoba, and Minnesota. Prevalence among wild foxes and coyotes is high, and may reach over 50% in some areas; however, even in these areas, transmission to humans has been low. Wild foxes, coyotes, and cats get infected when they eat Echinococcus multilocularis larvae in infected rodents, field mice, or voles. Cats are less susceptible than dogs, but because they probably catch and eat rodents more often, may also become infected. Once the animal becomes infected, the tapeworm matures in its intestine, lays eggs, and the infected animal passes eggs in the stool. These tapeworm eggs, which are directly infectious to other animals, are too tiny to see, and will stick to anything with which they come in contact. Coyotes, foxes, dogs, and cats are not harmed by the tapeworm and do not have symptoms of AHD.
Alveolar proteinosis
See: Pulmonary alveolar proteinosis.
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This dictionary contains 19186 terms.
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