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Alternative splicing
Alternative splicingA mechanism by which different forms of mature mRNAs (messengers RNAs) are generated from the same gene. Alternative splicing is a regulatory mechanism by which variations in the incorporation of the exons, or coding regions, into mRNA leads to the production of more than one related protein, or isoform. RELATED TERMS-------------------------------------- Mechanism The arrangement or association of the elements or parts of anything in relation to the effect they generate; the combination of mental processes by which an effect is generated. Gene 1. A unit of DNA that carries information for the biosynthesis of a specific product in the cell. 2. Ultimate unit by which inheritable characteristics are transmitted to succeeding generations in all living organisms. Genes are contained by, and arranged along the length of, the chromosome. The gene is composed of deoxyribonucleic acid (DNA). Each chromosome of each species has a definite number and arrangement of genes, which govern both the structure and metabolic functions of the cells and thus of the entire organism. Incorporation A primitive defense mechanism, operating unconsciously, in which the psychic representation of a person, or parts of the person, is figuratively ingested. Protein Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others. SIMILAR TERMS-------------------------------------- Alteplase Generic name of a tissue plasminogen activator produced by recombinant DNA technology. The brand name is Activase. See: Tissue plasminogen activator. Alternate hemiplegia See: Alternating hemiplegia of childhood. Alternate pathway The mechanism of complement activation that does not involve activation of the C1, C4, C2 pathway by antigen-antibody complexes, and begins with the activation of C3. Alternate Site Testing Using parts of the body other than the finger tips to obtain blood for blood glucose testing. Alternating hemiplegia of childhood A rare neurological disorder with frequent temporary episodes of paralysis of one side of the body (hemiplegia) usually beginning before the age of 18 months. The eye movements, face, or limbs can be paralysed on either side of the body, but on only one side at a time. The cause is unknown. Abbreviated AHC. Also known as alternating hemiplegia syndrome. One form of AHC has a favorable outlook. It occurs primarily at night, when a child awakens, and is apparently related to migraine. These children have no other mental or neurological impairments. Another form of AHC is more serious and may include mental impairment, balance and gait difficulties, excessive sweating, changes in body temperature, and seizures. Treatment with flunarizine , a calcium channel blocker, may help to reduce the severity and duration of attacks of paralysis. Alternating hemiplegia syndrome See: Alternating hemiplegia of childhood. Alternative hypothesis. The opposite of a null hypothesis. See null hypothesis, research hypothesis. Alternative medical system A system of alternative medicine built upon a complete system of theory and practice. Often, such systems have evolved apart from and earlier than the conventional medical approach used in the US or Europe. Alternative medical systems may have evolved in Western or non-Western cultures. Examples of alternative medical systems that have developed in Western cultures include homeopathic medicine and naturopathic medicine. Examples of systems that have developed in non-Western cultures include traditional Chinese medicine and Ayurveda. Alternative Medicine A broad category of treatment systems (eg chiropractic, herbal medicine, acupuncture, homeopathy, naturopathy, and spiritual devotions) or culturally based healing traditions such as Chinese, Ayurvedic, and Christian Science. Alternative medicines share the common characteristic of nonacceptance by the biomedical (ie mainstream Western) establishment. Alternative medicine is also referred to as "complementary medicine." The designation "alternative medicine" is not equivalent to holistic medicine, a narrower term Alternative pathway The mechanism of complement activation that does not involve activation of the C1, C4, C2 pathway by antigen-antibody complexes, and begins with the activation of C3. PREVIOUS AND NEXT TERMS-------------------------------------- Alternate hemiplegia See: Alternating hemiplegia of childhood. Alternating hemiplegia of childhood A rare neurological disorder with frequent temporary episodes of paralysis of one side of the body (hemiplegia) usually beginning before the age of 18 months. The eye movements, face, or limbs can be paralysed on either side of the body, but on only one side at a time. The cause is unknown. Abbreviated AHC. Also known as alternating hemiplegia syndrome. One form of AHC has a favorable outlook. It occurs primarily at night, when a child awakens, and is apparently related to migraine. These children have no other mental or neurological impairments. Another form of AHC is more serious and may include mental impairment, balance and gait difficulties, excessive sweating, changes in body temperature, and seizures. Treatment with flunarizine , a calcium channel blocker, may help to reduce the severity and duration of attacks of paralysis. Alternating hemiplegia syndrome See: Alternating hemiplegia of childhood. Alternative medical system A system of alternative medicine built upon a complete system of theory and practice. Often, such systems have evolved apart from and earlier than the conventional medical approach used in the US or Europe. Alternative medical systems may have evolved in Western or non-Western cultures. Examples of alternative medical systems that have developed in Western cultures include homeopathic medicine and naturopathic medicine. Examples of systems that have developed in non-Western cultures include traditional Chinese medicine and Ayurveda. Alternative splicing Altitude illness "Altitude illness (or altitude sickness) is a disorder caused by being at high altitude. It commonly occurs above 8,000 feet (2,440 meters). The cause of altitude illness is a matter of oxygen physiology. At sea level the concentration of oxygen is about 21% and the barometric pressure averages 760 mmHg. As altitude increases, the concentration remains the same but the number of oxygen molecules per breath is reduced. At 12,000 feet (3,658 meters) the barometric pressure is only 483 mmHg, so there are roughly 40% fewer oxygen molecules per breath. In order to oxygenate the body effectively, your breathing rate (even while at rest) has to increase. This extra ventilation increases the oxygen content in the blood, but not to sea level concentrations. Since the amount of oxygen required for activity is the same, the body must adjust to having less oxygen. In addition, high altitude and lower air pressure cause fluid to leak from the capillaries which can cause fluid build-up in both the lungs and the brain. Continuing to higher altitudes without proper acclimatization can lead to potentially serious, even life-threatening illnesses. Altitude, acclimatization to Adjustment to changes in altitude. The main cause of altitude sickness is going too high too fast. Given time, the body can adapt to the decrease in oxygen concentration at a specific altitude, process known as acclimatization. Altitude, high Altitude sickness occurs at high altitude. Altretamine Brand name: Hexalen. An oral drug used to treat ovarian cancer that has persisted or has recurred following treatment with other anti-cancer drugs. It was approved for this use by the FDA in 1990. Altretamine also has been used for treating lung cancer, although this is an off-label use. Aluminum poisoning See: Aluminum. We thank you for using the Medical Glossary to search for Alternative splicing. If you have a better definition for Alternative splicing than the one presented here, please let us know by making use of the suggest a term option. This definition of Alternative splicing may be disputed by other professionals. Our attempt is to provide easy definitions on Alternative splicing and any other medical topic for the public at large.
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