Medical Glossary

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19186
medical terms

Advanced glycosylation endproducts




Advanced glycosylation endproducts

The polymerized end-products of protein cross-linked with glucose. AGEs tend to adhere to capillaries and arteries. increasing the risk of heart disease, blindness, and kidney failure. AGEs are best estimated by the levels of glycosylated hemoglobin in the bloodstream.

RELATED TERMS
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Protein
Any of a group of complex organic compounds which contain carbon, hydrogen, oxygen, nitrogen, and usually sulfur, the characteristic element being nitrogen. Proteins, the principal constituents of the protoplasm of all cells, are of high molecular weight and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and each protein has a unique genetically defined amino acid sequence which determines its specific shape and function. Their roles include enzymatic catalysis, transport and storage, coordinated motion, nerve impulse generation and many others.

Glucose
The only simple carbohydrate that circulates in the bloodstream. Glucose is the primary fuel used by the brain. It can also be stored in the liver and muscles in a polymer form known as glycogen.

Capillaries
Tiny blood vessels between arteries and veins that distribute oxygen-rich blood to the body.

Arteries
Blood vessels that carry blood away from the heart to the arms, legs, head, body and organs.

Risk
In clinical trials, the probability of harm or discomfort for subjects, arising from the test product. Acceptable risk differs depending on the condition for which a product is being tested. A product for sore throat, for example, will be expected to have a low incidence of side effects. However, unpleasant side effects may be an acceptable risk when testing a promising treatment for a life-threatening illness.

Heart
The hollow, muscular organ responsible for pumping blood through the circulatory system.

Disease
Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

Blindness
Legal blindness is defined as: 1) visual acuity of 20/200 (only being able to see the big E on the eye chart) or less in the best eye even with the eyes corrected by glasses or contact lenses; or, 2) The peripheral visual field is reduced to 20 degrees of visual angle or less. Twenty degrees of visual angle is about the size of a one foot ruler held at arms length.

Kidney
One of the paired organs that excrete urine. The kidneys are bean-shaped organs (about 11 cm long, 5 cm wide, and 3 cm thick) lying on either side of the vertebral column, posterior to the peritoneum, about opposite the twelfth thoracic and first three lumbar vertebrae.

Hemoglobin
Hemoglobin is a substance contained within the red blood cells and is responsible for their color. It has the unique property of combining reversibly with oxygen and is the medium by which oxygen is transported within the body. It takes up oxygen as blood passes through the lungs and releases it as blood passes through the tissues.



SIMILAR TERMS
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Advair diskus 100-50
Advair diskus 100-50 is a prescription or over-the-counter drug which is (or once was) legal in the United States and possibly in other countries. Active ingredient(s): fluticasone propionate; salmeterol xinafoate .

Advair diskus 250-50
Advair diskus 250-50 is a prescription or over-the-counter drug which is (or once was) legal in the United States and possibly in other countries. Active ingredient(s): fluticasone propionate; salmeterol xinafoate .

Advair diskus 500-50
Advair diskus 500-50 is a prescription or over-the-counter drug which is (or once was) legal in the United States and possibly in other countries. Active ingredient(s): fluticasone propionate; salmeterol xinafoate .

Advance Directive
A document in which a person either states choices for medical treatment or designates someone who should make treatment choices if the person should become unable to make decisions. Most often the term refers to formal, written documents, but it can also be used to include spoken statements by the patient.

Advance directives
Documents (such as a Living Will) completed and signed by a person who is legally competent to explain his or her wishes for medical care should he or she become unable to make those decisions at a later time.

Advance grief
See: Anticipatory grief.

Advance medical directives
These directives pertain to treatment preferences and the designation of a surrogate decision-maker in the event that a person should become unable to make medical decisions on their own behalf. Advance directives generally fall into three categories: living will, power of attorney and health care proxy.

Advanced Cardiac Life Support
This is the more advanced skill set used in resuscitating cardiac arrest patients. This set starts with Basic Life Support, and extends it with invasive techniques such as intubation, specialized drugs, IV access and more sophisticated diagnostic techniques. This skill set is practiced out of the hospital by Paramedics and flight nurses, and in the hospital by most critical care personnel. It is also referred to as ALS and ACLS.

Advanced Glycation End Products (AGEs)
A group of compounds that may have a role in diabetes complications such as retinopathy, neuropathy, nephropathy, and vascular disease. At present it is not known if they are the cause or the consequence of the complications observed.

Advanced maternal age
Usually defined as age 35 or more for the mother at the time of delivery of her baby. Advanced maternal age predisposes to Down syndrome (trisomy 21). The risk of having a Down syndrome baby rises with maternal age. It essentially doubles from 1 in 725 at maternal age 32 to 1 in 365 at maternal age 35. And the risk continues to climb with the years and is 1 in 32 at maternal age 45.

Advanced paternal age
A man who is age 40 years or older at the time of conception. (There is no universally accepted definition of advanced paternal age but this criterion is often used in genetic counseling.)



PREVIOUS AND NEXT TERMS
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Adenosine triphosphate
The primary fuel used by cells to generate the biochemical reactions essential for life.

ATP
Adenosine triphosphate.

Adrenals
Located on the top of the kidneys, these glands that are responsible for the production of stress-related hormones such as cortisol, DHEA, and adrenaline.

Adrenocortiotrophic hormone
The hormone released from the pituitary gland. It interacts with receptors on the adrenal gland to begin the process of cortisol and DHEA production. ACTH uses the second messenger cyclic AMP to signal target cells in the adrenal gland.

ACTH
Adrenocortiotrophic hormone.

Advanced glycosylation endproducts

Aerobic capacity
The body's ability to process oxygen. It is a combination of lung capacity, the size of the capillaries, the pumping action of the heart, and transfer of oxygen from red blood cells to target tissues.

Aerobic exercise
Exercise with a low enough intensity to facilitate adequate oxygen transfer to the muscle cells so that no buildup of lactic acid is observed. This type of exercise is useful for reducing insulin levels and lowering blood glucose.

Amino acid
The fundamental building block of a protein molecule. A protein is composed of a chain of hundreds or thousands of amino acids. Our bodies can synthesize most of the amino acids. However, eight amino acids (called "essential amino acids") must be obtained from food.

Amygdala
The portion of the brain that processes emotions.

Anaerobic exercise
Exercise at an intensity that exceeds the ability to supply oxygen to the muscle cells leading to the buildup of lactic acid. Anaerobic exercise stimulates the synthesis of both growth hormone and testosterone.

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This dictionary contains 19186 terms.







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